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Development of Screening Guidelines and Clinical Criteria for Predementia Alzheimer’s Disease
The DESCRIPA StudyVisser P.J.a, b · Verhey F.R.J.a · Boada M.d · Bullock R.e · De Deyn P.P.h · Frisoni G.B.i · Frölich L.k · Hampel H.l-n · Jolles J.a · Jones R.f · Minthon L.o · Nobili F.j · Olde Rikkert M.c · Ousset P.-J.q · Rigaud A.-S.r · Scheltens P.b · Soininen H.t · Spiru L.u · Touchon J.s · Tsolaki M.v · Vellas B.q · Wahlund L.-O.p · Wilcock G.g · Winblad B.p
aDepartment of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, bDepartment of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, and cDepartment of Geriatrics, Radboud University Medical Centre, Nijmegen, The Netherlands; dFundació ACE, Barcelona, Spain; eKingshill Research Centre, Swindon, fThe Research Institute for the Care of Older People, Bath, and gDepartment of Care of Elderly, University of Bristol, Frenchay Hospital, Bristol, UK; hInstitute Born Bunge, ZNA Middelheim, University of Antwerp, Antwerp, Belgium; iLENITEM, IRCCS Fatebenefratelli, Brescia, and jClinical Neurophysiology Service Unit, Department of Endocrinological and Metabolic Sciences, University of Genoa, Genoa, Italy; kDivision of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, and lAlzheimer Memorial Centre and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany; mDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Trinity Centre for Health Sciences, and nThe Adelaide and Meath Hospital Incorporating The National Children’s Hospital, Dublin, Ireland; oClinical Memory Research Unit, Department of Clinical Sciences Malmö Lund University, Lund, and pNVS Department, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; qDepartment of Internal Medicine and Clinical Gerontology, Toulouse University Hospital, Toulouse, rDepartment of Geriatrics, Hopital Broca, Paris, and sInstitute National de la Santé et de la Recherche Medicinale INSERM U 888, Montpellier, France; tDepartment of Neurology, University and University Hospital of Kuopio, Kuopio, Finland; u‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania; vAristotle University of Thessaloniki, Memory and Dementia Centre, G. Papanicolaore General Hospital, Thessaloniki, Greece Corresponding Author
Pieter Jelle Visser
Department of Psychiatry and Neuropsychology, University of Maastricht
PO Box 616
NL–6200 MD Maastricht (The Netherlands)
Tel. +31 20 617 1721, Fax +31 842 134 161, E-Mail email@example.com
Background: There is an urgent need to identify subjects with Alzheimer’s disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer’s Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2–3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.
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