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Table of Contents
Vol. 21, No. 3-5, 1999
Issue release date: November 1999
Section title: Paper
Dev Neurosci 1999;21:400–406
(DOI:10.1159/000017390)

Path Analysis Shows That Increasing Ketogenic Ratio, but Not β-Hydroxybutyrate, Elevates Seizure Threshold in the Rat

Bough K.J.a · Chen R.S.b · Eagles D.A.a
Departments of aBiology and bAcademic and Information Technology Services, Washington, D.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: April 29, 2011
Issue release date: November 1999

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Previous work has identified several criteria that may be important in determining the efficacy of the ketogenic diet as a treatment for intractable epilepsy in children. The present study was designed to investigate the influence of four major variables on seizure threshold, i.e. ketogenic ratio, body weight, age at diet onset and β-hydroxybutyrate in rats. Path analysis was used to statistically model and quantify the causal relationships among variables. Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i.e. more fats vs. carbohydrates and proteins) and decreasing weight. Conversely, age at diet onset and plasma levels of β-OHB showed no causal relation to seizure resistance. These results suggest that the efficacy of the ketogenic diet is independent of the level of ketonemia but is markedly influenced by diet and growth.

© 1999 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: April 29, 2011
Issue release date: November 1999

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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