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Functions and Regulatory Mechanisms of Gq-Signaling PathwaysMizuno N. · Itoh H.
Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan Corresponding Author
Dr. H. Itoh
Department of Cell Biology, Graduate School of Biological Sciences
Nara Institute of Science and Technology
Takayama, Ikoma, Nara (Japan)
Tel. +81 743 72 5440, Fax +81 743 72 5449, E-Mail email@example.com
Gq family members of heterotrimeric G protein activate β isoforms of phospholipase C that hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate, leading to the protein kinase C activation and intracellular Ca2+ mobilization, respectively. To understand the functions and regulatory mechanisms of Gq-signaling pathways, we first introduce the Gαq-interacting proteins, which function as the effectors and the modulators of Gq. Next, we describe the Pasteurella multocida toxin and YM-254890, which are useful tools to investigate Gq signaling as activator and inhibitor, respectively. Finally, we discuss the physiological function of Gq in developmental brain, especially in neural progenitor cells.
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