For Manuscript Submission, Check or Review Login please go to Submission Websites List.
For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.
External Qi of Yan Xin Qigong Induces Apoptosis and Inhibits Migration and Invasion of Estrogen-Independent Breast Cancer Cells Through Suppression of Akt/NF-ĸB SignalingYan X.1,2 · Shen H.2 · Jiang H.3 · Hu D.4 · Zhang C.5 · Wang J.2 · Wu X.3,4
1Chongqing Institute of Traditional Chinese Medicine, Chongqing,2New Medical Science Research Institute, New York,3Brigham and Women’s Hospital and Harvard Medical School, Boston,4Dana-Farber Cancer Institute and Harvard Medical School, Boston,5McMaster University, Hamilton Corresponding Author
Dana-Farber Cancer Institute and Harvard Medical School
44 Binney Street, Boston, MA 02115 (USA)
Tel. +1 617 582 8303, Fax: +1 617 582 7992
The antitumor effects of external Qi of Yan Xin Qigong (YXQ-EQ) have been widely described over the past three decades. To gain a better understanding of the mechanisms underlying YXQ-EQ’s antitumor effects, in the present study we investigated its effects on growth, migration, invasion and apoptosis of breast cancer cells and the underlying molecular mechanisms. We show that YXQ-EQ treatment caused a time-dependent reduction in viability, blocked clonogenic growth and induced apoptosis in estrogen-independent breast cancer MDA-MB-231 cells. Furthermore, YXQ-EQ treatment blocked migration and invasion of MDA-MB-231 cells. Biochemically, YXQ-EQ treatment markedly inhibited constitutive and EGF-induced Akt phosphorylation. YXQ-EQ also substantially repressed NF-ĸB activity, resulting in decreased expression of anti-apoptotic Bcl-2, Bcl-XL, XIAP and survivin proteins. These findings suggest that YXQ-EQ may induce apoptosis and inhibition of migration and invasion of MDA-MB-231 cells through the repression of Akt/NF-ĸB signaling.
© 2010 S. Karger AG, Basel