Original Research Article
Subtle Deficits in Instrumental Activities of Daily Living in Subtypes of Mild Cognitive ImpairmentTeng E.a–c · Becker B.W.b · Woo E.c · Cummings J.L.c, d · Lu P.H.c
aNeurobehavior Unit and bGeriatric Research Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System, and Departments of cNeurology and dPsychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA
Edmond Teng, MD, PhD
Neurobehavior Unit (116AF), West Los Angeles VA Healthcare Center, Building 500
11301 Wilshire Boulevard
Los Angeles, CA 90073 (USA)
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Background/Aims: Greater cognitive and functional deficits in mild cognitive impairment (MCI) are associated with higher rates of dementia. We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices. Methods: We analyzed data from 1,108 MCI and 3,036 normal control subjects included in the National Alzheimer’s Coordinating Center Uniform Data Set who were assessed with the Functional Activities Questionnaire (FAQ). Results: IADL deficits were greater in amnestic than nonamnestic MCI, but within these subgroups, did not differ between those with single or multiple domains of cognitive impairment. FAQ indices correlated significantly with memory and processing speed/executive function. Conclusions: IADL deficits are present in both amnestic MCI and nonamnestic MCI but are not related to the number of impaired cognitive domains. These cross-sectional findings support previous longitudinal reports suggesting that cognitive and functional impairments in MCI may be independently associated with dementia risk.
© 2010 S. Karger AG, Basel
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