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|Table of Contents|
|Vol. 132, No. , 2008|
|Section title: Session III: Using Animal Genomics to Understand Animal Diseases|
Identification of Genes Involved with Tick Infestation in Bos taurus and Bos indicusKongsuwan K.1 · Piper E.K.2 · Bagnall N.H.1 · Ryan K.3 · Moolhuijzen P.3 · Bellgard M.3 · Lew A.4 · Jackson L.4 · Jonsson N.N.2
1CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, Australia;2School of Veterinary Science, University of Queensland, St Lucia, Australia;3Centre for Comparative Genomics, Murdoch University, Perth, Australia;4Department of Primary Industries and Fisheries, Moorooka, Australia
Tick resistant cattle could provide a potentially sustainable and environmentally sound method of controlling cattle ticks. Advances in genomics and the availability of the bovine genome sequence open up opportunities to identify useful and selectable genes controlling cattle tick resistance. Using quantitative real-time PCR and the Affymetrix bovine array platform, differences in gene expression of skin biopsies from tick resistant Bos indicus (Brahman) and tick susceptible Bos taurus (Holstein-Friesian) cattle following tick challenge were examined. We identified 138 significant differentially-expressed genes, including several immunological/host defence genes, extracellular matrix proteins, and transcription factors as well as genes involved in lipid metabolism. Three key pathways, represented by genes differentially expressed in resistant Brahmans, were identified; the development of the cell-mediated immune response, structural integrity of the dermis and intracellular Ca2+ levels. Ca2+, which is implicated in host responses to microbial stimuli, may be required for the enhancement or fine-tuning of transcriptional activation of Ca2+-dependant host defence signalling pathways.
© 2008 S. Karger AG, Basel