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Table of Contents
Vol. 23, Suppl. 1, 2010
Issue release date: September 2010
Section title: Paper
Free Access
Skin Pharmacol Physiol 2010;23(suppl 1):45–51

Clinical Use of Polihexanide on Acute and Chronic Wounds for Antisepsis and Decontamination

Eberlein T.a · Assadian O.b
aDermatologist/Allergologist, Palma, Spain; bInstitute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
email Corresponding Author

Ojan Assadian, MD, DTMH

Institute of Hygiene and Environmental Medicine

Ernst Moritz Arndt University Greifswald, Walther Rathenau Strasse 49a

DE–17489 Greifswald (Germany)

Tel. +49 3834 515 540, Fax +49 3834 515 541, E-Mail assadian@uni-greifswald.de

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Polihexanide is an antimicrobial compound suitable for clinical use in critically colonized or infected acute and chronic wounds. Its beneficial characteristic is attributable particularly to its broad antimicrobial spectrum, good cell and tissue tolerability, ability to bind to the organic matrix, low risk of contact sensitization, and wound healing promoting effect. In addition, no development of microorganism resistance during polihexanide use has been detected to date, nor does this risk appear imminent. The aim of therapy using polihexanide is to reduce the pathogen burden in a critically colonized or infected acute or chronic wound. An increasing number of articles on the subject of wound antisepsis with polihexanide can be found in the medical literature. However, there is still little published information on the practical use of polihexanide-containing wound antiseptics. The purpose of this review article is to describe the handling and the different possibilities of use of polihexanide-containing preparations, including the currently approved indications, contraindications and reservations. The use of polihexanide is not the only therapeutic option in management of wounds; therefore, priority is also given to prior surgical debridement and clarification of the cause of the underlying disease, including appropriate therapy.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 08, 2010
Issue release date: September 2010

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 6

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

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