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Table of Contents
Vol. 101, No. 1, 2012
Issue release date: December 2011
Section title: Review
Free Access
Neonatology 2012;101:1–7

Biomarkers in Neonatal Posthemorrhagic Hydrocephalus

Merhar S.
Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
email Corresponding Author

Stephanie Merhar, MD

Division of Neonatology, Cincinnati Children’s Hospital

3333 Burnet Ave ML 7009

Cincinnati, OH 45229 (USA)

Tel. +1 513 257 7749, E-Mail stephanie.merhar@cchmc.org

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Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the causes, diagnose brain injury, and predict neurodevelopmental outcomes. This systematic review summarizes studies on biomarkers of extracellular matrix activity, fibrinolysis/coagulation, hypoxia/cell death, and inflammation in the cerebrospinal fluid of infants with PHH.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 07, 2010
Accepted: December 09, 2010
Published online: July 27, 2011
Issue release date: December 2011

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

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