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Brain Activity Supporting Working Memory Accuracy in Patients with Paranoid Schizophrenia: A Functional Magnetic Resonance Imaging StudyWolf C.a · Linden S.a, b · Jackson M.C.a · Healy D.b · Baird A.c · Linden D.E.J.a, b · Thome J.c, d
aWolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, and bDepartment of Psychological Medicine and Neurology, Cardiff University, Cardiff, and cLaboratory of Molecular Psychiatry and Pharmacology, Institute of Life Science, School of Medicine, Swansea University, Swansea, UK; dDepartment of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany Corresponding Author
Prof. David Linden
MRC Centre for Neuropsychiatric Genetics and Genomics
Sir Henry Wellcome Building, Cardiff University School of Medicine
Cardiff CF14 4XN (UK)
Tel. +44 2920 687 928, E-Mail firstname.lastname@example.org
Background: Dysfunctional working memory (WM) has been recognized as one of the most consistent deficits in schizophrenia. Studies that investigated the neural correlates of WM-related pathology by comparing patients with schizophrenia and control participants have produced controversial results, reporting task-related hyper- or hypoactivity in frontoparietal networks. Method: We addressed this question by comparing BOLD signals for accurate responses during a WM task for emotional faces between a homogeneous group of high-performing patients and a control group. Results: Our results confirm previous findings of left prefrontal hyperactivity contrasted with hypoactivity in right prefrontal cortex to support WM performance. We also extend previous work by reporting enhanced activity in higher visual areas of patients during encoding and maintenance. Conclusion: Our findings and those of the literature can be integrated into a model, where preserved visual cognition in high-functioning patients with hypofrontality is explained by activation of contralateral homologue areas combined with enhanced recruitment of sensory areas.
© 2011 S. Karger AG, Basel