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Table of Contents
Vol. 3, No. 3, 2011
Issue release date: April 2011
Section title: Review
J Innate Immun 2011;3:289–297

The Role of Natural Killer Cells in the Defense against Listeriamonocytogenes Lessons from a Rat Model

Naper C.b · Shegarfi H.a · Inngjerdingen M.b · Rolstad B.a
aDepartment of Anatomy, Institute of Basic Medical Sciences, University of Oslo, and bInstitute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
email Corresponding Author

Dr. Bent Rolstad

Department of Anatomy, Institute of Basic Medical Sciences

University of Oslo

NO–0316 Oslo (Norway)

Tel. +47 2285 1212, E-Mail bent.rolstad@medisin.uio.no

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Ly49 receptors in rodents, like killer cell immunoglobulin-like receptors in humans, regulate natural killer (NK) cell activity. Although inhibitory Ly49 receptors clearly recognize classical major histocompatibility complex class I (MHC-I) molecules, the role for the activating Ly49 receptors has been less well understood. Here, we discuss recent data from a rat model for listeriosis. Rats depleted of NK cells, or more specifically the Ly49 receptor-bearing cells, showed increased bacterial loads in their spleen. Athymic nude rats with no functional T cells but increased numbers of Ly49-expressing NK cells were more resistant to infection, indicating a central role of NK cells in early immune defense against Listeria in this species. Listeria infection of macrophages or enteric epithelial cells led to upregulation of MHC-I, including nonclassical (Ib) molecules not regularly recognized by T cells. We have shown that activating Ly49 receptors are more efficiently stimulated when binding to upregulated class Ib antigens on infected cells. From this we postulate that activating Ly49 receptors may have a sentinel function in the early immune response against Listeria in detecting diseased cells ‘flagged’ by increased MHC-Ib expression.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: November 08, 2010
Accepted: January 10, 2011
Published online: March 23, 2011
Issue release date: April 2011

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN

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