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An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast – Its Diagnosis and the Role of Radiotherapy in its ManagementRock K. · Rangaswamy G. · O’Sullivan S. · Coffey J.
Department of Radiation Oncology, St. Luke’s Hospital, Rathgar, Dublin 6, Ireland Corresponding Author
Dr. Kathy Rock, St. Luke’s Hospital, Rathgar, Dublin 6, Ireland, Tel. +353 1 4065-000 / +353 86 8420854, Fax -222, firstname.lastname@example.org
Background: Primary lymphoma of the breast accounts for 0.04–0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. Case Report: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin‘s lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no ‘B’ symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. Conclusion: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.
© 2011 S. Karger AG, Basel