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Effect of L-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled TrialAlizadeh M.a · Safaeiyan A.b · Ostadrahimi A.c · Estakhri R.d · Daneghian S.e · Ghaffari A.e · Gargari B.P.c
aDepartment of Biochemistry and Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, bDepartment of Vital Statistics and Epidemiology and cDepartment of Biochemistry and Nutrition, Faculty of Health and Nutrition, Nutrition Research Center, dLiver and Gastrointestinal Disease Research Center, and eStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Background/Aims: We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants were randomly assigned to a control diet (HDEL), L-arginine (5 g/day) and HDEL, selenium (200 µg/day) and HDEL or L-arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results: After 6 weeks, L-arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fasting concentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L-arginine and selenium significantly reduced the fasting concentration of nitric oxides (NOx), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NOx. HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion: These data indicate the beneficial effects of L-arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NOx and TG.
© 2012 S. Karger AG, Basel