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A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis NigricansKondo Y.a · Umegaki N.a · Terao M.a · Murota H.a · Kimura T.b · Katayama I.a
aDepartment of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, and bDepartment of Internal Medicine, Suita Municipal Hospital, Suita-City, Japan Corresponding Author
Department of Dermatology Integrated Medicine
Osaka University Graduate School of Medicine
2-2, Yamadaoka, Suita-City 565-0871 (Japan)
Tel. +81 6 6879 3031, E-Mail email@example.com
Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren’s syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy.
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