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Original Report: Patient-Oriented, Translational Research

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function

Kuwabara M.a,c,d · Bjornstad P.a, b · Hisatome I.e · Niwa K.d · Roncal-Jimenez C.A.a · Andres-Hernando A.a · Jensen T.a · Milagres T.a · Sato Y.a · Garcia G.a · Ohno M.c · Lanaspa M.A.a · Johnson R.J.a

Author affiliations

aSchool of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO, and bChildren's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA; cToranomon Hospital, Department of Cardiology, and dSt. Luke's International Hospital, Cardiovascular Center, Tokyo, and eTottori University Graduate School of Medical Sciences, Division of Regenerative Medicine and Therapeutics, Yonago, Japan

Related Articles for ""

Am J Nephrol 2017;45:330-337

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: December 21, 2016
Accepted: January 23, 2017
Published online: March 11, 2017
Issue release date: April 2017

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: While elevated serum uric acid level (SUA) is a recognized risk factor for chronic kidney disease, it remains unclear whether change in SUA is independently associated with change in estimated glomerular filtration rate (eGFR) over time. Accordingly, we examined the longitudinal associations between change in SUA and change in eGFR over 5 years in a general Japanese population. Methods: This was a large, single-center, retrospective 5-year cohort study at St. Luke's International Hospital, Tokyo, Japan, between 2004 and 2009. We included 13,070 subjects (30-85 years) in our analyses whose data were available between 2004 and 2009. Of those, we excluded 492 subjects with eGFR <60 mL/min/1.73 m2 at baseline. In addition to examining the entire cohort (n = 12,578), we stratified our analyses by baseline eGFR groups: 60-90, 90-120, and ≥120 mL/min/1.73 m2. Linear and logistic regressions models were applied to examine the relationships between baseline and change in SUA, change in eGFR, and rapid eGFR decline (defined as the highest quartile of change in eGFR), adjusted for age, gender, body mass index, abdominal circumference, hypertension, dyslipidemia, and diabetes mellitus. Results: After multivariable adjustments including baseline eGFR, 1 mg/dL increase in baseline SUA was associated with greater odds of developing rapid eGFR decline (OR 1.27, 95% CI 1.17-1.38), and 1 mg/dL increase in SUA over 5 years was associated with 3.77-fold greater odds of rapid eGFR decline (OR 3.77, 95% CI 3.35-4.26). Conclusions: Elevated baseline SUA and increasing SUA over time were independent risk factors for rapid eGFR decline over 5 years.

© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: December 21, 2016
Accepted: January 23, 2017
Published online: March 11, 2017
Issue release date: April 2017

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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