Chromosome painting refines the history of genome evolution in hares and rabbits (order Lagomorpha)Robinson T.J.a · Yang F.b,c · Harrison W.R.a
aDepartment of Zoology, University of Stellenbosch, Stellenbosch (South Africa) bCentre for Veterinary Science, University of Cambridge, Cambridge (UK) cKunming Institute of Zoology, The Chinese Academy of Sciences, Yunnan (People’s Republic of China)
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Fluorescence in situ hybridization (FISH) was used to define homologous segments among representatives of 7 of the 11 recognized leporid genera. Chromosome painting using 22 rabbit chromosome-specific paints derived from flow-sorted chromosomes revealed that at least 18 fusions and six fissions differentiate the extant karyotypes from the presumed ancestral state (2n = 48). The riverine rabbit, Bunolagus monticularis, has the most derived karyotype, differing from the ancestor by seven fusions and five fissions, followed by Pronolagus rupestris, with four fusions and one fission. These findings are consistent with the proposed Palaeolaginae/Leporinae dichotomy in the lagomorphs. The molecular cytogenetic data allow for a refinement of the structural changes that have shaped genome evolution in this group of mammals and underscore the rapid radiation of the Leporidae suggested by mitochondrial DNA sequence data.
© 2002 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.