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Table of Contents
Vol. 38, No. 3, 2004
Issue release date: May – June
Section title: Paper
Caries Res 2004;38:230–235

A Caries Vaccine?

The State of the Science of Immunization against Dental Caries

Russell M.W.a · Childers N.K.b · Michalek S.M.c · Smith D.J.d · Taubman M.A.d
aDepartments of Oral Biology and Microbiology and Immunology, University at Buffalo, Buffalo, N.Y., Departments of bOral Biology and cMicrobiology, University of Alabama at Birmingham, Birmingham, Ala., and dDepartment of Immunology, Forsyth Institute, Boston, Mass., USA
email Corresponding Author

Michael W. Russell, PhD

Department of Microbiology, Farber 138

University at Buffalo, 3435 Main Street

Buffalo, NY 14214 (USA)

Tel. +1 716 829 2790, Fax +1 716 829 2169, E-Mail russellm@buffalo.edu


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  8. Childers NK, Zhang SS, Michalek SM: Oral immunization of humans with dehydrated liposomes containing Streptococcus mutans glucosyltransferase induces salivary immunoglobulin A2 antibody responses. Oral Microbiol Immunol 1994;9:146–153.
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  12. Hamada S, Horikoshi T, Minami T, Kawabata S, Hiraoka J, Fujiwara T, Ooshima T: Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans. Infect Immun 1991;59:4161–4167.
  13. Harokopakis E, Hajishengallis G, Greenway TE, Russell MW, Michalek SM: Mucosal immunogenicity of a recombinant Salmonella typhimurium-cloned heterologous antigen in the absence or presence of co-expressed cholera toxin A2/B subunits. Infect Immun 1997;65:1445–1454.
  14. Harrod T, Martin M, Russell MW: Long-term persistence and recall of immune responses in aged mice after mucosal immunization. Oral Microbiol Immunol 2001;16:170–177.
  15. Hatta H, Tsuda K, Ozeki M, Kim M, Yamamoto T, Otake S, Hirasawa M, Katz J, Childers NK, Michalek SM: Passive immunization against dental plaque formation in humans: Effect of a mouth rinse containing egg yolk antibodies (IgY) specific to Streptococcus mutans. Caries Res 1997;31:268–274.
  16. Huang Y, Hajishengallis G, Michalek SM: Induction of protective immunity against Streptococcus mutans colonization after mucosal immunization with attenuated Salmonella enterica serovar typhimurium expressing an S. mutans adhesin under the control of in vivo-inducible nirB promoter. Infect Immun 2001;69:2154–2161.
  17. Jenkinson HF, Lamont RJ: Streptococcal adhesion and colonization. Crit Rev Oral Biol Med 1997;8:175–200.
  18. Jespersgaard C, Hajishengallis G, Huang Y, Russell MW, Smith DJ, Michalek SM: Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferase. Infect Immun 1999;67:6543–6549.
  19. Koga T, Oho T, Shimazaki Y, Nakano Y: Immunization against dental caries. Vaccine 2002;20:2027–2044.
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  23. Li Y, Caufield PW: The fidelity of initial acquisition of mutans streptococci by infants from their mothers. J Dent Res 1995;74:681–685.
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  25. Loimaranta V, Carlén A, Olsson J, Tenovuo J, Syväoja EL, Korhonen H: Concentrated bovine colostral whey proteins from Streptococcus mutans/Strep. sobrinus immunized cows inhibit the adherence of Strep. mutans and promote the aggregation of mutans streptococci. J Dairy Res 1998;65:599–607.
  26. Ma JKC, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, Van Dolleweerd C, Mostov K, Lehner T: Generation and assembly of secretory antibodies in plants. Science 1995;268:716–719.
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  29. Martin MH, Metzger DJ, Michalek SM, Connell TD, Russell MW: Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins, LT-IIa and LT-IIb. Infect Immun 2000;68:281–287.
  30. Michalek SM, Childers NK, Katz J, Dertzbaugh M, Zhang S, Russell MW, Macrina FL, Jackson S, Mestecky J: Liposomes and conjugate vaccines for antigen delivery and induction of mucosal immune responses. Adv Exp Med Biol 1992;327:191–198.
  31. Mitoma M, Oho T, Michibata N, Okano K, Nakano Y, Fukuyama M, Koga T: Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries. Infect Immun 2002;70:2721–2724.
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  34. Russell MW: Mucosal immunity; in Ellis RW, Brodeur BR (eds): New Bacterial Vaccines. Georgetown, Landes Bioscience, 2003.
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  36. Russell MW, Moldoveanu Z, White PL, Sibert GJ, Mestecky J, Michalek SM: Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect Immun 1996;64:1272–1283.
  37. Russell MW, Wu H-Y: Distribution, persistence, and recall of serum and salivary antibody responses to peroral immunization with protein antigen I/II of Streptococcus mutans coupled to the cholera toxin B subunit. Infect Immun 1991;59:4061–4070.
  38. Russell RRB, Beighton D, Cohen B: Immunization of monkeys (Macaca fascicularis) with antigens purified from Streptococcus mutans. Br Dent J 1982;152:81–84.
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  42. Smith DJ, King WF, Godiska R: Passive transfer of immunoglobulin Y antibody to Streptococcus mutans glucan binding protein B can confer protection against experimental dental caries. Infect Immun 2001;69:3135–3142.
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  46. Smith DJ, Trantolo DJ, King WF, Gusek EJ, Fackler PH, Gresser JD, De Souza VL, Wise DL: Induction of secretory immunity with bioadhesive poly(D,L-lactide-co-glycolide) microparticles containing Streptococcus sobrinus glucosyltransferase. Oral Microbiol Immunol 2000;15:124–130.
  47. Takahashi I, Okahashi N, Matsushita K, Tokuda M, Kanamoto T, Munekata E, Russell MW, Koga T: Immunogenicity and protective effect against oral colonization by Streptococcus mutans of synthetic peptides of a streptococcal surface protein antigen. J Immunol 1991;146:332–336.
  48. Taubman MA, Holmberg CJ, Smith DJ: Immunization of rats with synthetic peptide constructs from the glucan-binding or catalytic region of mutans streptococcal glucosyltransferase protects against dental caries. Infect Immun 1995;63:3088–3093.
  49. Vajdy M, Lycke N: Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant. Immunology 1993;80:197–203.
  50. Weintraub JA, Hilton JF, White JM, Hoover C, Pelino JE, Tran K, Wycoff K, Larrick JW, Yu L, Featherstone JDB: Results of a plant-derived mutans streptococci antibody clinical trial (abstract 201). J Dent Res 2001;80(special issue).
  51. Wu HY, Abdu S, Stinson D, Russell MW: Generation of female genital tract antibody responses by local or central (common) mucosal immunization. Infect Immun 2000;68:5539–5545.
  52. Zhang P, Jespersgaard C, Lamberty-Mallory L, Katz J, Huang Y, Hajishengallis G, Michalek SM: Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Infect Immun 2002;70:6779–6787.