Sample pictures from
'Molecules of Life & Mutations'

Ligands ('Small Molecules')
1.1 Non-Peptidic 'Small Molecules'


Picture9
One Ca2+ ion (magenta atom ball) held between two carboxylate ions (grey atom balls) of two glutamate residues of the adhesion protein E-selectin (grey backbone, shown in part) PDB 1ESL

Picture15
Beta-Phenylethylamine (wireframe + atom balls as dot clouds, except for nitrogen: grey ball)

Picture7a
Mitomycin (grey atom balls) within  dsDNA (magenta wireframe) PDB 199D

Picture7b
Daunomycin (white atom balls) within ssDNA (wireframe) PDB 110D

1.2 Peptidic and Proteohormones

Picture5
Transforming growth factor beta (white "coat") PDB 1TFG

1.3 Peptidic Toxins

Picture6
Choleratoxin beta subunit-pentamer (backbone) + glycane moieties on interacting target cell surface proteins (atomic balls) PDB 1CHB

Ligand-Binding Proteins ('Large Molecules')
2 Enzymes

Picture17
RNase inhibitor (white backbone) + RNase (magenta backbone) PDB 1A4Y

3 Membrane Receptors

Picture18
Rhodopsin (backbone)+ all-trans Retinal (wireframe, oxygen: magenta atom balls, nitrogen: white atom ball) PDB 1BRD

Picture11+12
Human growth hormone (HGH) (magenta backbone) complexed between two extracellular domains of two HGH receptors (grey backbones), their transmembrane helices shown schematically PDB 3HHR

4 Signal Transduction Proteins

Picture1
Calmodulin (grey backbone) + 4 Ca 2+ (magenta atom balls) + contacting helix of myosin light chain kinase (white atom balls) PDB 1CDL

5 Multimodular Adhesion Proteins

Picture2
Fibronectin modules (grey and magenta backbone), one with RGD motif (atom balls) PDB 1FBR

6 DNA-Binding Proteins

Picture14
Tumor supressor protein p53-dimer (one monomer shown as grey atom balls, the other as magenta backbone) + dsDNA (wireframe) PDB 1TSR

7 Immunological Proteins

Picture3
Antibody Fab fragment (backbone to the left) + HIV gp120 (magenta wireframe, center) + CD4 (white wireframe) PDB 1GC1

8 Miscellaneous Macromolecules


Picture4
Proteasomal complex (white 'coat') PDB 1PML