| Sample
pictures from 'Molecules of Life & Mutations' Ligands ('Small Molecules') 1.1 Non-Peptidic 'Small Molecules' |
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One
Ca2+ ion (magenta atom ball) held between two carboxylate ions
(grey atom balls) of two glutamate residues of the adhesion protein E-selectin
(grey backbone, shown in part) PDB 1ESL |
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Beta-Phenylethylamine
(wireframe + atom balls as dot clouds, except for nitrogen: grey ball) |
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Mitomycin (grey
atom balls) within dsDNA (magenta wireframe) PDB 199D |
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Daunomycin (white
atom balls) within ssDNA (wireframe) PDB 110D |
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1.2 Peptidic and Proteohormones |
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Transforming
growth factor beta (white "coat") PDB 1TFG |
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1.3 Peptidic Toxins |
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Choleratoxin
beta subunit-pentamer (backbone) + glycane moieties on interacting target
cell surface proteins (atomic balls) PDB 1CHB |
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Ligand-Binding Proteins ('Large Molecules') 2 Enzymes |
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RNase inhibitor
(white backbone) + RNase (magenta backbone) PDB 1A4Y |
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3 Membrane Receptors |
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Rhodopsin (backbone)+
all-trans Retinal (wireframe, oxygen: magenta atom balls, nitrogen: white
atom ball) PDB 1BRD |
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Human growth
hormone (HGH) (magenta backbone) complexed between two extracellular domains
of two HGH receptors (grey backbones), their transmembrane helices shown
schematically PDB 3HHR |
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4 Signal Transduction Proteins |
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Calmodulin (grey
backbone) + 4 Ca 2+ (magenta atom balls) + contacting helix of myosin light
chain kinase (white atom balls) PDB 1CDL |
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5 Multimodular Adhesion Proteins |
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Fibronectin
modules (grey and magenta backbone), one with RGD motif (atom balls) PDB
1FBR |
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6 DNA-Binding Proteins |
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Tumor supressor
protein p53-dimer (one monomer shown as grey atom balls, the other as magenta
backbone) + dsDNA (wireframe) PDB 1TSR |
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7 Immunological Proteins |
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Antibody Fab
fragment (backbone to the left) + HIV gp120 (magenta wireframe, center)
+ CD4 (white wireframe) PDB 1GC1 |
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8 Miscellaneous Macromolecules |
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Proteasomal
complex (white 'coat') PDB 1PML |
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