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	Review ‘This volume of Monographs in Human Genetics is a welcome addition to the series. Martin Zenker has invited experts within this clinical and molecular field to contribute chapters, including a History of Noonan syndrome and related disorders by Dr. Noonan herself. The format of each chapter follows a pattern which allows each chapter to be read independently and provides a well referenced review of the current knowledge. This does lead to some repetition if one is reading the volume as a whole but that is not a significant criticism. … Each of the clinical chapters is a well written review of the clinical features and related complications of the relevant disorder with good clinical images and illustrations…..The chapters related to the molecular genetics of each condition are well organized and emphasize the contribution of each gene within the overall signaling cascade… This volume is a timely addition to the literature and provides a welcome review of the dysregulation of the Ras-MAPK pathway in Noonan syndrome and the related syndromes. It is very easy to navigate with clear chapters and references. I can certainly recommend it to anyone who wishes to update themselves on this fascinating, evolving story.’ Sally J. Davies (Human Genetics, Vol. 125, No. 5–6, 2009)
	Copyright© 2010 S. Karger AG, Basel