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	NADPH Oxidases in Innate Immunity Reactive oxygen species (ROS) formed by phagocytic leukocytes play a primary role in host defense, but also perpetuate both acute and chronic cellular inflammatory responses. Roles for ROS in non-phagocytic cells include intracellular signaling, proliferation, apoptosis, and innate immunity. NADPH oxidases (Nox) are enzymes that generate ROS under regulated conditions to contribute to host defense in epithelial barrier tissues (respiratory epithelium, gut, vasculature, etc). This issue would focus on how Nox regulate innate immunity in such tissues, as well as how Nox themselves might be regulated under normal and pathogical conditions.
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