Print Close WindowThere is a dynamic interplay in virally infected cells between the ability of the cell to preserve its viability and fight the infection and of viruses to replicate. The outcome of this struggle determines the spread of the infection, symptoms of disease and sometimes the survival of the host. While late in infection, adaptive responses develop and can clear infections, it is the critical early hours and days where innate immunity is essential to limit infection and to direct initial inflammation. We will explore many aspects of this complex interaction. The role of Pathogen Recognition Receptors, such as Toll and intracellular helicases, are essential in delivering signals of infection. Because host responses, including interferon production can be so effective in limiting viral replication, many viruses have developed evasive pathways. Viral N-linked glycans can modulate host innate immune responses. In addition, a number of intracellular pathways are potentially therapeutic targets during viral replication. This special focus section will elucidate some aspects of the dynamic interactions of innate immune responses and viral infections.
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