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Corruption of Innate Immunity by Bacterial Proteases

All bacteria of the environment, including commensals and pathogens, produce proteases that promote their survival. Fortunately, only a small fraction of the expressed proteases in any pathogen, present a threat to the host, thus to be considered virulence factors. Bacterial proteases span a wide range of mechanisms and recently several targets of innate immunity have been elucidated. Consequently, the search for inhibitors of theses enzymes to be used as anti-bacterial agents will continue to drive this thriving field of research. This issue will discuss novel perspectives on bacterial proteases versus innate immunity.

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