Ontogeny of Pig Discrete Peyer’s Patches: Distribution and Morphometric Analysis

Vol. 68, No. 6, 2000

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Original Paper

Ontogeny of Pig Discrete Peyer's Patches: Distribution and Morphometric Analysis
L.H.C. Makala^a, T. Kamada^a, Y. Nishikawa^a, H. Nagasawa^a, I. Igarashi^a, K. Fujisaki^a, N. Suzuki^a, T. Mikami^a, K. Haverson^b, M. Bailey^b, C.R. Stokes^b, P.W. Bland^b

^aNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan,
^bDivision of Molecular and Cellular Biology, Department of Clinical Veterinary Science, University of Bristol, Bristol, UK

Address of Corresponding Author

Pathobiology 2000;68:275-282 (DOI: 10.1159/000055938)

Key Words

Ontogeny
Discrete Peyer's patch
Morphometric analysis
Pig

Abstract

We investigated the development of lymphoid and non-lymphoid cells in discrete Peyer's patches (PP) of the pig using immuno-histology and image analysis. In newborn piglets discrete PP were mainly populated by CD2+, CD3+ T cells, and major histocompatibility complex class II+ cells, many of which were of macrophage and dendritic cell lineage. Four days after birth, cells were localized in defined regions: the follicle; the inter-follicular area and the dome region. Compartmentalization within the follicle started about 6 days after birth. The first signs of secondary follicles were seen from about 14 days. The pig discrete PP attained their mature structure at about 3 weeks after birth. Here we show that despite the demonstration at birth of the cell types that support antigen processing and presentation, PP did not fully differentiate morphologically until at least this time when antigen can be handled in an efficient manner.

Author Contacts

Prof. H. Nagasawa
National Research Center for Protozoan Diseases
Obihiro University of Agriculture and Veterinary Medicine
Inada-Cho, Obihiro, Hokkaido 080-8555 (Japan)
Tel. +81 155 49 5644, Fax +81 155 49 5643, E-Mail nrcpmi@obihiro.ac.jp

Article Information

Received: Received: December 11, 2000
Accepted: March 5, 2001
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 49

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