Case Report

Nephrotic Syndrome with Portal, Splenic and Renal Vein Thrombosis
A Case Report
Yuki Etoh^a,b, Isao Ohsawa^a, Takayuki Fujita^a, Yoshinobu Fuke^a, Morito Endo^a, Hiroyuki Ohi^a, Kazunari Kumasaka<sup>b

a</sup>Internal Medicine II, Nihon University School of Medicine, and
^bDepartment of Laboratory Medicine, Nihon University School of Medicine, Tokyo, Japan

Address of Corresponding Author

Nephron 2002;92:680-684 (DOI: 10.1159/000064107)

  Key Words

• Nephrotic syndrome
• Portal vein thrombosis
• Lipoprotein(a)
• Anticoagulation therapy

  Abstract

Background: Thromboembolism is known as a major complication of nephrotic syndrome, but only 4 cases of portal vein thrombosis have been reported as a complication of nephrotic syndrome. All of these 4 cases had acute symptoms, and 3 of 4 were in relapsing phase of nephrotic syndrome when thrombi were found. We describe here a case of 51-year-old woman with fresh nephrotic syndrome that was asymptomatically complicated by portal, splenic and renal vein thrombosis. Conclusion: In the presence of fresh nephrotic syndrome of minimal change, asymptomatic and widely distributed, including portal vein, thrombus formation occurred. If the clinical course shows resistance to therapy, we must consider the complication of venous thrombosis. Anticoagulant therapy with heparin and warfarin was effective and all thrombi disappeared without any other complications.

Copyright © 2002 S. Karger AG, Basel

  Author Contacts

Yuki Etoh, MD
Department of Laboratory Medicine, Nihon University School of Medicine
30-1, Oyaguchi-kamimachi Itabashi-ku
Tokyo, 173-8610 (Japan)
Tel. +81 3 3972 8111, Fax +81 3 3957 7757, E-Mail yetoh@med.nihon-u.ac.jp

  Article Information

Accepted: March 21, 2002
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 3, Number of References : 20