Review

Role of CD83 in the Immunomodulation of Dendritic Cells
Matthias Lechmann, Elisabeth Zinser, Antje Golka, Alexander Steinkasserer

Department of Dermatology, University of Erlangen-Nürnberg, Erlangen, Germany

Address of Corresponding Author

Int Arch Allergy Immunol 2002;129:113-118 (DOI: 10.1159/000065883)

  Key Words

• Dendritic cells
• CD83

  Abstract

Glycoprotein CD83 is one of the best-known maturation markers for human dendritic cells (DCs). The fact that CD83 is strongly upregulated together with co-stimulatory molecules such as CD80 and CD86 during DC maturation suggests it plays an important role in the induction of immune responses. Infection studies with herpes simplex virus type 1 (HSV-1) and the inhibition of the CD83 mRNA specific transport from the nucleus to the cytoplasm suggested a possible functional role for CD83. The first clear proof that CD83 is indeed important for DC biology came from recently performed studies using a soluble form of the extracellular CD83 domain. DC-mediated T cell proliferation could be completely inhibited using this recombinant molecule. Additional studies elucidated immunostimulatory as well as regulatory effects of the CD83 molecule. Furthermore, CD83-/- knockout mice revealed a block in CD4+ T cell generation, a new possible immunomodulatory function of CD83.

Copyright © 2002 S. Karger AG, Basel

  Author Contacts

Correspondence to: Prof. Alexander Steinkasserer
Department of Dermatology, University of Erlangen-Nürnberg
Hartmannstrasse 14, D-91052 Erlangen (Germany)
Tel. +49 9131 853 6725, Fax +49 9131 853 5799
E-Mail steinkasserer@derma.imed.uni-erlangen.de

  Article Information

Number of Figures : 0, Number of Tables : 0, Number of References : 26