Nitric Oxide and Effect of a Radical Scavenger N-<i>tert</i>-butyl-α-phenylnitrone on Stroke in a Rat Model

Vol. 73, No. 2, 2005

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Original Paper

Nitric Oxide and Effect of a Radical Scavenger N-tert-butyl--phenylnitrone on Stroke in a Rat Model
Kieko Saito, Masahiko Ikeda, Hisashi Yoshioka, Takako Tomita

Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan

Address of Corresponding Author

Pharmacology 2005;73:76-80 (DOI: 10.1159/000081223)

Key Words

Electron spin resonance
Nitric oxide
N-tert-butyl--phenylnitrone
Stroke-prone SHR
Stroke
Oxidative stress
Superoxide
Peroxynitrite

Abstract

To characterize the role of nitric oxide (NO) in stroke, NO was measured using an in vivo microdialysis technique and electron spin resonance spectrometry in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP), stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). The brain dialysate NO level was higher in SHRSP than in WKY. NO was not detected in M-SHRSP hippocampus microdialysate after stroke except after the administration of N-tert-butyl- alpha -phenylnitrone (PBN). In addition, very little NO was generated in M-SHRSP brain tissue with hemorrhage. These data demonstrate an association between NO and stroke in M-SHRSP. Further, PBN administration results in maintenance of NO levels after stroke in M-SHRSP.

Author Contacts

Kieko Saito
Institute for Environmental Sciences
University of Shizuoka, 52-1 Yada
Shizuoka 422-8526 (Japan)
Tel./Fax +81 54 2645719, E-Mail saitok@smail.u-shizuoka-ken.ac.jp

Article Information

Received: December 2, 2003
Accepted: May 19, 2004
Published online: September 30, 2004
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 26

Medline Abstract (ID 15467301)

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