A Normal Organ Antigen and Its Corresponding Antibodies in Pathological Human Sera

Vol. 135, No. 3, 2004

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Original Paper

A Normal Organ Antigen and Its Corresponding Antibodies in Pathological Human Sera
Felix Milgrom, Donna Czechowski

Department of Microbiology and Immunology, State University of New York at Buffalo, N.Y., USA

Address of Corresponding Author

Int Arch Allergy Immunol 2004;135:243-246 (DOI: 10.1159/000081310)

Key Words

Normal organ antigen
Pathological human sera
Wassermann antibodies
Bovine organ extract

Abstract

Previous studies on the appearance in pathological human sera of antibodies to an antigen of normal mammalian organs were continued. In gel precipitation reactions, antibodies combining with saline extracts of mammalian organs were found in 20 of 63 cancer sera and in 4 of 15 syphilis sera, but only in 3 of 56 other pathological sera. Furthermore, an identical antigen was demonstrated in 5 of 58 pathological sera. The antigen under study did not belong to any group of known heterophile antigens and it was devoid of organ and tissue specificity.

Author Contacts

Correspondence to: Dr. Felix Milgrom
Department of Microbiology and Immunology
School of Medicine, SUNY
Buffalo, NY 14214 (USA)
Tel. +1 716 829 3816, Fax +1 716 829 2175, E-Mail milgrom@buffalo.edu

Article Information

Received: May 5, 2004
Accepted: June 30, 2004
Published online: October 4, 2004
Number of Print Pages : 4
Number of Figures : 4, Number of Tables : 0, Number of References : 14

Medline Abstract (ID 15467376)

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