Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients

Vol. 210, Suppl. 1, 2005

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RALGA The First Association of Retinaldehyde and Glycolic Acid. A New Compound for the Acne Patient with Depigmenting Properties. Based on a Satellite Symposium Held at the 12th Congress of the EADV, Barcelona, October 2003. Chaired by: W.J. Cunliffe, B. Dréno, A. Katsambas, H. Gollnick and J.-H. Saurat

Biochemistry

Topical Retinaldehyde with Glycolic Acid: Study of Tolerance and Acceptability in Association with Anti-Acne Treatments in 1,709 Patients
B. Dréno^a, T. Nocera^b, F. Verrière^b, M.P. Vienne^b, C. Ségard^b, S. Vitse^b, C. Carré^c

^aDepartment of Dermatology, CHU Nantes, Nantes,
^bPierre Fabre Dermo-Cosmétique, Laboratoires Dermatologiques Avène, Lavaur, and
^cQuanta Medical Group, Rueil-Malmaison, France

Address of Corresponding Author

Dermatology 2005;210 (Suppl. 1):22-29 (DOI: 10.1159/000081500)

Key Words

Retinaldehyde
Glycolic acid
Acne

Abstract

Background: Retinaldehyde (RAL), a key metabolite between vitamin A and retinoic acid, acts by modulating differentiation and proliferation of keratinocytes, which is of interest in acne lesions, mainly retentional lesions. Glycolic acid increases the exfoliation of corneocytes explaining its mild activity on retentional lesions. Thus, RAL and glycolic acid combined in the same product (Diacnéal^®) have complementary activities which can be of interest for acne patients. The aim of this study was to evaluate the tolerance of Diacnéal used by 1,709 acne patients in combination with their usual acne products except retinoids. Results: This study demonstrated a very good tolerance of Diacnéal when used with other acne treatments for 90 days. Complaints about side-effects were rare. Moreover, the significant decrease in both inflammatory and retentional lesions between day 0 and day 90 indicates that Diacnéal could amplify the efficiency of other anti-acne products used at the same time by the patients. The subjective evaluation of the preparation's efficacy by investigators and patients was strongly favourable. Conclusion: These data show that a combination of RAL 0.1% and glycolic acid 6% may be used in association with other topical anti-acne treatments (benzoyl peroxide and topical antibiotics) with an excellent tolerance.

Author Contacts

Prof. B. Dréno
Department of Dermatology, CHU Nantes, Hôtel-Dieu
Place A.-Ricordeau
FR-44035 Nantes Cedex 1 (France)
Tel. +33 2 400 831 18, Fax +33 2 400 831 17, E-Mail bdreno@wanadoo.fr

Article Information

Number of Print Pages : 8
Number of Figures : 7, Number of Tables : 5, Number of References : 19

Medline Abstract (ID 15724104)

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