Relationship of Serum Cardiac Markers following Successful Percutaneous Coronary Intervention and Subsequent Exercise Capacity in Patients with Chronic Stable Angina: A Pilot Study

Vol. 103, No. 2, 2005

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General Cardiology

Relationship of Serum Cardiac Markers following Successful Percutaneous Coronary Intervention and Subsequent Exercise Capacity in Patients with Chronic Stable Angina: A Pilot Study
Simon G. Williams^a, Rod H. Stables^a, David J. Wright^a, Steve Taylor^b, Douglas Thompson^c, Lip-Bun Tan^c

^aCardiothoracic Centre, Liverpool,
^bDepartment of Mathematical Sciences, University of Liverpool, Liverpool,
^cMolecular Vascular Medicine, Chemical Biochemistry and Cardiology Departments, Leeds General Infirmary, Leeds, UK

Address of Corresponding Author

Cardiology 2005;103:63-67 (DOI: 10.1159/000082049)

Key Words

Coronary artery disease
Peak oxygen consumption
Percutaneous coronary intervention
Troponin T

Abstract

We performed a pilot study to assess the significance of modest, asymptomatic, elevated serum cardiac markers - troponin T (TnT) and creatinine kinase-MB (CK-MB) - 18-24 h following successful elective percutaneous coronary intervention (PCI) and to explore their relationship with changes in aerobic exercise capacity, as measured by peak oxygen consumption (VO₂), 6 weeks following the procedure. Twenty-three patients with single-vessel disease and chronic angina performed an incremental cardiopulmonary exercise test before and 6 weeks after successful uncomplicated PCI. A venous blood sample was taken at rest before PCI and 18-24 h after the procedure. Successful PCI resulted in a trend towards an increased peak VO₂ [21.62 ± 0.64 (pre) vs. 23.03 ± 0.75 ml/ kg/min (post), p = 0.07; mean ± SEM]. There was a significant increase [median (IQR)] in TnT, from 0.00 (0.00) µg/l at baseline increasing to 0.02 (0.03) µg/l at 18-24 h, p = 0.002. CK-MB levels showed no significant difference. In the group of 15/23 (65%) patients with an elevation in serum TnT (0.01 µg/l), 18-24 h after successful PCI, there was no significant increase in peak VO₂ [23.31 ± 0.96 (pre) vs. 23.89 ± 1.09 ml/kg/min (post), p = 0.57]. In 8 (35%) patients with no rise in TnT at 18-24 h, a significant increase in peak VO₂ was observed following successful PCI [23.10 ± 0.91 (pre) vs. 25.09 ± 0.75 ml/kg/min (post), p = 0.02]. Although 7 of these 8 patients increased their peak VO₂, the absence of a TnT rise at 18-24 h was not significantly associated with an increase in peak VO₂ following successful PCI (p = 0.18). To confirm these interesting initial results and investigate the relationship of serum cardiac markers following successful PCI and subsequent exercise capacity, further studies are required.

Author Contacts

Dr. Simon Williams
Cardiothoracic Centre, Thomas Drive
Liverpool, L14 3PE (UK)
Tel. +44 151 228 1616, Fax +44 151 293 2254
E-Mail drsgwilliams@hotmail.com

Article Information

Received: April 28, 2004
Accepted after revision: May 8, 2004
Published online: November 10, 2004
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 18

Medline Abstract (ID 15539783)

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