Antihypertensive Effect of 5-HT<sub>1A</sub> Agonist Buspirone and 5-HT<sub>2B</sub> Antagonists in Experimentally Induced Hypertension in Rats

Vol. 73, No. 3, 2005

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Original Paper

Antihypertensive Effect of 5-HT_1A Agonist Buspirone and 5-HT_2B Antagonists in Experimentally Induced Hypertension in Rats
J.R. Shingala^b, R. Balaraman^a

^aDepartment of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kalabhavan, Baroda, and
^bTorrent Research Centre, Ahmedabad, India

Address of Corresponding Author

Pharmacology 2005;73:129-139 (DOI: 10.1159/000082114)

Key Words

5-Hydroxytryptamine
Buspirone
SB204741
SB200646
Deoxycorticosterone acetate
Hypertension

Abstract

We investigated the antihypertensive effect of 5-HT_1A agonist (buspirone) and 5-HT_2B antagonists (SB204741 and SB200646) in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats. Experiments were divided into two sets: in the first set, sham-operated control and DOCA-treated hypertensive rats received buspirone (1 mg/kg/day p.o. for 4 weeks) and in the second set, in vivo and in vitro studies were carried out. In the case of in vivo studies, sham-operated control and DOCA-treated hypertensive rats received SB204741 or SB200646 (1 mg/kg/week i.v. for 4 weeks). Blood pressure was measured weekly by tail-cuff method. After completion of the treatment schedule, blood pressure and vascular reactivity to various agonists like 5-HT, noradrenaline and adrenaline were recorded. Chronic administration of buspirone, SB204741 and SB200646 produced a significant reduction in blood pressure and vascular reactivity to agonists in DOCA-salt hypertensive rats, implying an antihypertensive effect. However, chronic administration of the same drugs in sham control rats did not alter blood pressure and vascular reactivity to various agonists. For in vitro studies a similar treatment schedule was followed as in vivo studies and a cumulative concentration response curve of 5-HT was recorded on isolated thoracic aorta. Treatment with 5-HT_2B antagonists shifted the concentration response curve of 5-HT to the right on isolated aorta. We conclude that 5-HT_1A agonist and 5-HT_2B antagonists possess an antihypertensive effect.

Author Contacts

R. Balaraman
Department of Pharmacy, Faculty of Technology and Engineering
The M.S. University of Baroda, Kalabhavan
Baroda 390 001, Gujarat (India)
E-Mail rbalaraman2000@yahoo.com

Article Information

Received: May 6, 2004
Accepted after revision: July 14, 2004
Published online: November 11, 2004
Number of Print Pages : 11
Number of Figures : 7, Number of Tables : 0, Number of References : 36

Medline Abstract (ID 15539790)

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