Autoimmune Disorders in Two Patients with Myelodysplastic Syndrome and 5q Deletion

Vol. 113, No. 2, 2005

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Case Report

Autoimmune Disorders in Two Patients with Myelodysplastic Syndrome and 5q Deletion
A.A.N. Giagounidis^a, S. Haase^a, U. Germing^b, M. Heinsch^a, C. Aul^a

^aMedizinische Klinik II, St. Johannes Hospital, Duisburg,
^bKlinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

Address of Corresponding Author

Acta Haematol 2005;113:146-149 (DOI: 10.1159/000083454)

Key Words

5q anomaly
Autoimmune diseases
Myelodysplastic syndromes

Abstract

Autoimmune diseases occurring concurrently with myelodysplastic syndrome (MDS) with deletion del(5q) including band q31 are very rare and have only been reported twice in the medical literature. We present two additional cases, one patient with del(5q) and trisomy 21 who suffered from rheumatoid arthritis and one patient with isolated del(5q) and autoimmune hemolytic anemia. Both patients had mild leukopenia and severe transfusion-dependent anemia. The rheumatoid arthritis was treated with antirheumatics without additional immunosuppressive medication. Autoimmune hemolytic anemia was controlled with long-term steroid administration. This patient developed additional trisomy 21 2 years after the initial diagnosis of del(5q). Contrary to previous reports on autoimmune disorders in MDS mentioning improvements of hematological function in response to steroid administration, neither of our patients had a hematological improvement under corticosteroids.

Author Contacts

Dr. A.A.N. Giagounidis
Medizinische Klinik II, St. Johannes Hospital
An der Abtei 7-11
DE-47166 Duisburg (Germany)
Tel. +49 203 5460, Fax +49 203 5462249, E-Mail gia@krebs-duisburg.de

Article Information

Received: December 1, 2003
Accepted after revision: June 30, 2004
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 23

Medline Abstract (ID 15802895)

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