Extraintestinal Manifestations of Crohn’s Disease

Vol. 71, No. 1, 2005

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Extraintestinal Manifestations of Crohn's Disease
Pascal Juillerat^a, Christian Mottet^a, Florian Froehlich^{a, b}, Christian Felley^a, John-Paul Vader^c, Bernard Burnand^c, Jean-Jacques Gonvers^a, Pierre Michetti^a

^aDivision of Gastroenterology and Hepatology, Lausanne University Medical Center, Lausanne;
^bGastrointestinal Department, University of Basle, Basle, and
^cInstitute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland

Address of Corresponding Author

Digestion 2005;71:31-36 (DOI: 10.1159/000083870)

Key Words

Crohn's disease
Inflammatory bowel disease
Extraintestinal manifestations
Ankylosing spondylitis
Pyoderma gangrenosum
Primary sclerosing cholangitis
Uveitis
Extraintestinal manifestations of CD, treatment

Abstract

In each case of extraintestinal manifestations of Crohn's disease, active disease, if present, should be treated to induce remission, which may positively influence the course of most concomitant extraintestinal manifestations. For some extraintestinal manifestations, however, a specific treatment should be introduced. This latter part of disease management will be discussed in this chapter, in particular for pyoderma gangrenosum, uveitis, spondylarthropathy - axial arthropathy - and primarysclerosing cholangitis, which have also been described in quiescent Crohn's disease. Few new drugs for the treatment of extraintestinal manifestations of Crohn's disease have been developed in the past and only the role of infliximab has increased in Crohn's disease-related extraintestinal manifestations. Drugs specifically aimed at this treatment, stemming from a few randomized controlled studies or case series, are sulfasalazine, 5-ASA, corticosteroids, azathioprine or 6-mercaptopurine, methotrexate, infliximab, dapsone and cyclosporine or tacrolimus.

Author Contacts

Pierre Michetti, MD
Division of Gastroenterology and Hepatology
Lausanne University Medical Center
Rue du Bugnon 46, CH-1011 Lausanne (Switzerland)
Tel. +41 21 3140690, Fax +41 21 3140707, E-Mail Pierre.Michetti@hospvd.ch

Article Information

Published online: February 4, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 0, Number of References : 86

Medline Abstract (ID 15711047)

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