Follow-Up Investigations of Tau Protein and S-100B Levels in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease

Vol. 19, No. 5-6, 2005

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Original Research Article

Follow-Up Investigations of Tau Protein and S-100B Levels in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease
Lukas Cepek^a, Petra Steinacker^a, Brit Mollenhauer^a, Birgitt Wiese^b, Barbara Ciesielczyk^a, Mirko Bibl^c, Jens Wiltfang^e, Inga Zerr^a, Walter Schulz-Schaeffer^d, Hans A. Kretzschmar^f, Sigrid Poser^a, Markus Otto^a

Departments of
^aNeurology,
^bMedical Informatics,
^cPsychiatry,
^dNeuropathology, University of Göttingen, Göttingen;
^ePsychiatry, University of Nuremberg/Erlangen, Nuremberg/Erlangen, and
^fNeuropathology, University of Munich, Munich, Germany

Address of Corresponding Author

Dement Geriatr Cogn Disord 2005;19:376-382 (DOI: 10.1159/000084708)

Key Words

Creutzfeldt-Jakob disease
S-100B
Tau protein

Abstract

Background: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. Patients and Methods: We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. Results: Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. Conclusion: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases.

Author Contacts

Markus Otto, MD
Department of Neurology, University of Göttingen
Robert-Koch Strasse 40
DE-37070 Göttingen (Germany)
Tel. +49 551 39 8404, Fax +49 551 39 14449, E-Mail motto@gwdg.de

Article Information

Accepted: November 1, 2004
Published online: March 30, 2005
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 1, Number of References : 29

Medline Abstract (ID 15802913)

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