Extramammary Paget’s Disease Not Only Mimicking but Also Accompanying Condyloma acuminatum

Vol. 210, No. 4, 2005

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Case Report

Extramammary Paget's Disease Not Only Mimicking but Also Accompanying Condyloma acuminatum
A Case Report
Yumi Honda^a, Kiyofumi Egawa^b

Departments of
^aSurgical Pathology and
^bDermatology, Kumamoto University School of Medicine, Kumamoto, Japan

Address of Corresponding Author

Dermatology 2005;210:315-318 (DOI: 10.1159/000084756)

Key Words

Extramammary Paget's disease, verrucous
Human papillomavirus
Condyloma acuminatum

Abstract

Although its significance remains unknown, it has recently been reported that epidermal papillomatous hyperplasia could be frequently found in extramammary Paget's disease (EMPD). The simultaneous occurrence of EMPD and various human-papillomavirus (HPV)-associated neoplasms has also been reported. We report a case of a perianal EMPD with multiple verrucous papules on its surface. Histologically, the verrucous papules consisted of two distinct histological patterns; one showed numerous Paget's cells within the hyperplastic epidermis with papillomatosis, and the other showed the features compatible with condyloma acuminatum (CA). HPV-6 DNA was demonstrated in koilocytic keratinocytes of the CA by in situ hybridization. No positive signal was obtained for targeted HPV type 6/11/16/18/31/33 DNA in either the verrucous or plaque EMPD. Since the verrucous papules were localized on the plaque of EMPD, our case suggests that some undetermined EMPD-related factors may contribute to the development of epithelial hyperplasia, including HPV-associated neoplasms.

Author Contacts

Yumi Honda, MD, PhD
Department of Surgical Pathology, Kumamoto University School of Medicine
1-1-1 Honjo, 860-8556 Kumamoto (Japan)
Tel. +81 96 373 5795, Fax +81 96 373 5796
E-Mail yumih@kaiju.medic.kumamoto-u.ac.jp

Article Information

Received: June 17, 2004
Accepted: August 16, 2004
Number of Print Pages : 4
Number of Figures : 4, Number of Tables : 0, Number of References : 13

Medline Abstract (ID 15942218)

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