Address of Corresponding Author

Caries Res 2005;39:191-194 (DOI: 10.1159/000084797)

  Key Words

• Fluoride-release
• Intraoral devices
• Microdiffusion

  Abstract

The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F^-/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface of the first maxillary molar teeth of 20 subjects (age 20-23 years). Morning and evening salivary and urinary samples were collected 5 days before the study and every day for the 1st week, then once a week for 1 month. Fluoride ion measurements were done using the microdiffusion method. The salivary and urinary fluoride concentrations were significantly raised during the treatment period (p < 0.05). Morning salivary fluoride levels were higher than evening salivary fluoride levels (p < 0.05) whereas evening urinary fluoride levels were higher than morning urinary fluoride levels (p < 0.05). The statistically significant increase in salivary fluoride levels indicates a caries-preventive role for this device.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Prof. Dr. Alev Alaçam
Gazi Üniversitesi, Dihekimlii Fakültesi
Pedodonti Anabilim Dali
TR-06510 Emek, Ankara (Turkey)
Tel. +90 312 2138344, Fax +90 312 2239226, E-Mail alacam@gazi.edu.tr

  Article Information

Received: August 28, 2003
Accepted after revision: July 24, 2004
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 0, Number of References : 24