Fosfomycin Tromethamine in Uncomplicated Urinary Tract Infections: A Clinical Study

Vol. 51, No. 2-3, 2005

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Clinical Trial

Fosfomycin Tromethamine in Uncomplicated Urinary Tract Infections: A Clinical Study
Giovanni Bonfiglio^a, Roberto Mattina^b, Antonina Lanzafame^b, Esmeralda Cammarata^a, Gianna Tempera^a, on behalf of the Italian Medici Medicina Generale (MMG) Group

^aDepartment of Microbiology, University of Catania, Catania, and
^bInstitute of Microbiology, University of Milan, Milan, Italy

Address of Corresponding Author

Chemotherapy 2005;51:162-166 (DOI: 10.1159/000085625)

Key Words

Fosfomycin
Urinary tract infection, uncomplicated
Urinary pathogens
Antibiotic resistance

Abstract

The aim of our study was to verify if the empiric therapy with a single dose of 3 g fosfomycin tromethamine in patients with uncomplicated urinary tract infections (UTIs) was able to clinically resolveand to microbiologically eradicate the infection. A total of 387 out of the 400 patients (274 cases with acute and 113 cases with recurrent uncomplicated UTIs) were enrolled in the clinical study. Clinical and microbiological assessments were performed before and at 8-10 days after the administration. At follow-up high clinical recovery (88.9%) and bacteriological (94.9%) eradication rates were achieved. Gastrointestinal side effects were found in only 4.3% of patients. In conclusion, a single-dose administration regimen of fosfomycin tromethamine should be encouraged as a first choice of drug therapy for uncomplicated UTIs.

Author Contacts

Dr. Giovanni Bonfiglio
Department of Microbiology, University of Catania
Via Androne 81
IT-95124 Catania (Italy)
Tel. +39 095 317 485, Fax +39 095 325 032, E-Mail bonfigio@unict.it

Article Information

Received: March 28, 2004
Accepted after revision: October 12, 2004
Published online: May 9, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 30

Medline Abstract (ID 15886477)

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