Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans

Vol. 72, No. 4, 2005

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Clinical Investigations

Lack of an Association between Interleukin-12 Receptor 1 Polymorphisms and Tuberculosis in Koreans
Hye Won Lee, Hee Seok Lee, Deog Kyeom Kim, Dong Seok Ko, Sung Koo Han, Young-Soo Shim, Jae-Joon Yim

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea

Address of Corresponding Author

Respiration 2005;72:365-368 (DOI: 10.1159/000086249)

Key Words

Tuberculosis
Genetic susceptibility
Interleukin-12 receptor
Single nucleotide polymorphism
Koreans

Abstract

Background: The fact that only 10% of people infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) suggests the presence of genetic factors in the pathogenesis of TB. To date, a number of single nucleotide polymorphisms (SNPs) in several candidate genes have been proposed as genetic risk factors of TB; however, reports are conflicting. Objectives: We investigated whether SNPs in the interleukin (IL)-12 receptor beta 1 gene are associated with TB in Koreans. Methods: One hundred and fifteen patients with bacteriologically or pathologically confirmed TB and 151 healthy anonymous blood donors were enrolled. The genotypes of 5 SNPs on IL-12 receptor beta 1 gene, +705A/G (Q214R), +1158T/C (M365T), +1196G/C (G378R), +1637G/A (A525T) and +1664 C/T (P534S), were determined by PCR-RFLP. Results: No difference was observed between TB patients and controls in terms of the genotype frequencies of the 5 SNPs of the IL-12 receptor beta 1 gene or of their haplotypes. Conclusions: In view of the finding that these SNPs have been reported to be associated with TB in the Japanese and Moroccan populations, our results may reflect racial differences in genetic susceptibility to TB.

Author Contacts

Jae-Joon Yim, MD
Department of Internal Medicine, Seoul National University College of Medicine
28 Yongon-Dong, Chongno-Gu
Seoul, 110-744 (Republic of Korea)
Tel. +82 2 760 2059, Fax +82 2 762 9662, E-Mail yimjj@snu.ac.kr

Article Information

Received: July 6, 2004
Accepted after revision: November 22, 2004
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 3, Number of References : 29

Medline Abstract (ID 16088278)

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