Congenital Cystic Adenomatoid Malformation in the Fetus: A Hypothesis of Its Development

Vol. 20, No. 5, 2005

Free Abstract Article (References) Article (PDF 101 KB)

Paper

Congenital Cystic Adenomatoid Malformation in the Fetus: A Hypothesis of Its Development
Ema Kulwa, Tessie Tharakan, Laxmi Baxi

Department of Obstetrics and Gynecology, Sloane Hospital for Women, Columbia University Medical Center of New York Presbyterian Hospital and College of Physicians and Surgeons of Columbia University, New York, N.Y., USA

Address of Corresponding Author

Fetal Diagn Ther 2005;20:472-474 (DOI: 10.1159/000086836)

Key Words

Congenital cystic adenomatoid malformation
Fetal ascites
Polyhydramnios
Retinoic acid

Abstract

We present a case of congenital cystic adenomatoid malformation of the lung diagnosed at 34 weeks of gestation in the setting of polyhydramnios. The fetus had CCAM in the L lung, with mediastinal shift to the right and ascites. The neonate underwent drainage of cysts and subsequent left lung lobar resection with improvement in respiratory function. The pathology of CCAM is reviewed in detail. We speculate the role of alcohol as a teratogen through retinoic acid at 8-10 weeks of gestation when fetal lungs are actively developing.

Author Contacts

Laxmi Baxi, MD, Department of Obstetrics and Gynecology, Sloane Hospital for Women
Columbia University Medical Center of New York Presbyterian Hospital and
College of Physicians and Surgeons of Columbia University
622 West 168 Street, New York, NY 10032 (USA)
Tel. +1 212 305 2407, Fax +1 212 305 5269, E-Mail lvb1@columbia.edu

Article Information

Received: October 20, 2004
Accepted after revision: December 20, 2004
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 18

Medline Abstract (ID 16113577)

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