Proton Magnetic Resonance Spectroscopy and Magnetoencephalographic Estimation of Delta Dipole Density: A Combination of Techniques That May Contribute to the Diagnosis of Alzheimer’s Disease

Vol. 20, No. 2-3, 2005

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Original Research Article

Proton Magnetic Resonance Spectroscopy and Magnetoencephalographic Estimation of Delta Dipole Density: A Combination of Techniques That May Contribute to the Diagnosis of Alzheimer's Disease
Alberto Fernández^a, Juan Manuel García-Segura^{b, c}, Tomás Ortiz^a, Julia Montoya^b, Fernando Maestú^a, Pedro Gil-Gregorio^d, Pablo Campo^a, Juan Viaño^b

^aCentro de Magnetoencefalografía Dr. Pérez-Modrego, Universidad Complutense de Madrid, Madrid,
^bUnidad de Resonancia Magnética, Clínica Ntra. Sra. del Rosario, Madrid,
^cDepartamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad Complutense de Madrid, Madrid,
^dServicio de Geriatría, Hospital Universitario San Carlos de Madrid, Madrid, Spain

Address of Corresponding Author

Dement Geriatr Cogn Disord 2005;20:169-177 (DOI: 10.1159/000087094)

Key Words

Magnetoencephalography
Proton magnetic resonance spectroscopy
Alzheimer's disease
Myoinositol/N-acetyl aspartate (mI/NAA)
Delta dipole density

Abstract

Whole-head magnetoencephalographic recordings were obtained from 10 patients with Alzheimer's disease (AD) and 10 healthy controls in a resting position. Spectroscopic examinations were performed by means of a 1.5-tesla whole-body scanner in the temporoparietal regions of both hemispheres. The relationship between ¹H-MRS-based and magnetoencephalography (MEG)-based measures and their conjoined capability to improve the diagnosis of AD were investigated in this study. Logistic regression analyses were performed. Three separated logistic models were calculated for ¹H-MRS-based metabolites, low-frequency magnetic activity, and the combination of both measures. A combined myoinositol/N-acetyl aspartate (mI/NAA)-delta dipole density (DD) model predicted the diagnosis with 90% sensitivity and 100% specificity. Additionally, the combination of temporoparietal mI/NAA and delta DD values explained the variability of individuals' cognitive status. The results support the notion that a multidisciplinary approach may improve the understanding and diagnosis of AD.

Author Contacts

Prof. Dr. Tomás Ortiz Alonso
Centro MEG Dr. Pérez-Modrego, Facultad de Medicina
Pabellón 8, avda Complutense s\n, Universidad Complutense de Madrid
ES-28040 Madrid (Spain)
Tel. +34 91 3942 292, Fax +34 91 3942 294, E-Mail cmeg@ect.ucm.es

Article Information

Accepted: March 7, 2005
Published online: July 15, 2005
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 4, Number of References : 45

Medline Abstract (ID 16020946)

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