Effectiveness of Antiinfectives

Vol. 51, No. 5, 2005

Free Abstract Article (References) Article (PDF 119 KB)

Review

Effectiveness of Antiinfectives
Ramona McLoughlin, Colm O'Morain

Adelaide and Meath Hospital, and Trinity College, Dublin, Ireland

Address of Corresponding Author

Chemotherapy 2005;51:243-246 (DOI: 10.1159/000087250)

Key Words

Compliance
Eradication
Helicobacter pylori
Resistance

Abstract

Background:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. Treatment: First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-line therapy, consisting of a proton pump inhibitor, bismuth, metronidazole, and tetracycline, in the case of failure, is chosen as the most cost-effective method of H. pylori eradication. Conclusion: The effectiveness of these antiinfectives is limited by lack of compliance with treatment regimens, and increasing antibiotic resistance.

Author Contacts

Dr. Ramona McLoughlin
Adelaide and Meath Hospital
Tallaght
Dublin 24 (Ireland)
Tel. +353 141 438 51, Fax +353 141 438 50, E-Mail rmcloug@tcd.ie

Article Information

Presented at the 1st World Conference on Dosing of Antiinfectives: Dosing the Magic Bullets in Nürnberg, Germany, September 9-11, 2004.

Received: September 29, 2004
Accepted after revision: March 10, 2005
Published online: July 26, 2005
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 0, Number of References : 42

Medline Abstract (ID 16088120)

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