Early Detection of Thinning of Retinal Nerve Fiber Layer in Glaucomatous Eyes by Optical Coherence Tomography 3000: Analysis of Retinal Nerve Fiber Layer Corresponding to the Preserved Hemivisual Field

Vol. 38, No. 1, 2006

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Original Paper

Early Detection of Thinning of Retinal Nerve Fiber Layer in Glaucomatous Eyes by Optical Coherence Tomography 3000: Analysis of Retinal Nerve Fiber Layer Corresponding to the Preserved Hemivisual Field
Ryo Asaoka^a, Rumiko Ishii^a, Nobuo Kyu^b, Yoshihiro Hotta^a, Miho Sato^a

^aDepartment of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, and
^bKyu Eye Clinic, Shizuoka, Japan

Address of Corresponding Author

Ophthalmic Res 2006;38:29-35 (DOI: 10.1159/000088549)

Key Words

Optical Coherence Tomography 3000
Glaucoma
Retinal nerve fiber layer
Scanning laser ophthalmoscopy

Abstract

The retinal nerve fiber layer (RNFL) thickness was measured with the optical coherence tomography using version 3.0 software (OCT3000) in 153 eyes of 153 normal subjects. The mean of the average RNFL thickness over the entire 360° in the control group was 92.5 ± 12.9 µm which was significantly thinner than the normative data of 95.9 ± 11.4 µm included with the OCT3000 (p < 0.01). The RNFL thickness decreased with increasing age (p < 0.01, r = -0.395). The RNFL thickness was also measured in 53 eyes of 53 patients with glaucoma whose superior (13 eyes) or inferior (40 eyes) perimetric hemifields were normal. Only the RNFL thickness corresponding to the preserved perimetric hemifields were measured by OCT3000 and scanning laser ophthalmoscopy (SLO). The RNFL thickness in the superior and inferior 30° sectors, the maximum and average RNFL thickness in the superior (S_max and S_avg), and inferior quadrants (I_max and I_avg) were analyzed.The S_max, S_avg, I_max, I_avg, and the RNFL thickness in the superior (p< 0.05), superotemporal and inferotemporal sectors (p<0.01) in the glaucoma patients without a nerve fiber layer defect (SLO) were significantly thinner than in the control subjects in same age. OCT3000 measurements showed that the RNFL thickness in glaucomatous eyes with normal perimetric visual fields and SLO was significantly thinner than the RNFL thickness in normal eyes.

Author Contacts

Ryo Asaoka, MD
Department of Ophthalmology, Hamamatsu University School of Medicine
1-20-1 Handayama
Hamamatsu City 431-3192 (Japan)
Tel. +81 53 435 2256, Fax +81 53 435 2372, E-Mail ryoasa@orchid.plala.or.jp

Article Information

Received: December 13, 2004
Accepted after revision: April 18, 2005
Published online: September 23, 2005
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 25

Medline Abstract (ID 16192746)

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