Address of Corresponding Author

Fetal Diagn Ther 2006;21:1-7 (DOI: 10.1159/000089039)

  Key Words

• DiGeorge sequence
• Placenta
• Artery hypoplasia
• Vessel calcifications

  Abstract

This work describes some placental alterations found in a partial form of DiGeorge sequence, namely, hypoplasia of a cord artery with internal calcification of an extensive endoluminal thrombosis, and widespread calcification of microthrombi in the arteries of the second and third order villous branches. Hypoplasia of a cord artery is a relatively rare event, and is also associated with malformations of the gastroenteric and cardiovascular system, as sometimes described in the DiGeorge sequence. Interesting placental alterations are reported and their likely physiopathologic basis and pathogenic correlation discussed in order to give a better and more comprehensive picture of the DiGeorge sequence in which the correlated placental alterations are not sufficiently known.

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Ezio Fulcheri
Institute of Pathological Anatomy and Histology
University of Genoa, Via De Toni 14
IT-16132 Genoa (Italy)
Tel. +39 010 3537816, Fax +39 010 3537803, E-Mail ana.pat@unige.it

  Article Information

Received: November 27, 2003
Accepted after revision: July 13, 2004
Number of Print Pages : 7
Number of Figures : 5, Number of Tables : 0, Number of References : 31