Triploidy in a Growth Discordant Twin Pregnancy after Intracytoplasmic Sperm Injection Treatment

Vol. 21, No. 1, 2006

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Paper

Triploidy in a Growth Discordant Twin Pregnancy after Intracytoplasmic Sperm Injection Treatment
Case Report
Inanc Mendilcioglu^a, Mualla Ozcan^b, Gulseren Bagci^b, Mehmet Simsek^a, Sinan Kursun^a, Guven Luleci^b, Omur Taskin^a

Departments of
^aObstetrics and Gynaecology, and
^bGenetics, Akdeniz University, School of Medicine, Antalya, Turkey

Address of Corresponding Author

Fetal Diagn Ther 2006;21:65-67 (DOI: 10.1159/000089050)

Key Words

Intracytoplasmic sperm injection
Selective feticide
Triploidy
Growth discordant
Twin

Abstract

Objective: We report on a case of a triploidy in one fetus of a twin pregnancy who presented with the findings of growth discordance. Methods: Three weeks' difference between fetuses in ultrasonographic measurements in the first trimester was observed in a twin pregnancy following intracytoplasmic sperm injection (ICSI) treatment for male infertility. Hydrocephaly developed in the growth-discordant fetus subsequently. Amniocentesis for both fetuses and selective feticide for the abnormal one was performed at 19weeks' gestation through a single insertion. Fetal karyotype of the abnormal one was 69,XXX and the healthy one was 46,XX. Conclusion: Early developed growth discordance in a twin pregnancy may be a sign of chromosomal abnormality such as triploidy. Those cases should be karyotyped without delay to decrease preterm delivery risk of possible selective feticide.

Author Contacts

Inanc Mendilcioglu, MD
Department of Obstetrics and Gynaecology
School of Medicine, Akdeniz University, Dumlupinar Bulvari
TR-07070 Arapsuyu, Antalya (Turkey)
Tel. +90 242 2430450, Fax +90 242 2274490, E-Mail imendilcioglu@yahoo.com

Article Information

Received: September 29, 2004
Accepted after revision: December 8, 2004
Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 12

Medline Abstract (ID 16354978)

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