The Role of Growth Hormone in Neural Development

Vol. 64, Suppl. 3, 2005

Free Abstract Article (Fulltext) Article (PDF 171 KB)

Methods to Determine Insulin Sensitivity in Clinical Practice. Growth Hormone and Cognition.
Editor(s): Ranke, M.B. (Tübingen), Vance, M.L. (Charlottesville, Va.)

Neurocognition

The Role of Growth Hormone in Neural Development
Arjan Scheepens, Tanja A.E. Möderscheim, Peter D. Gluckman

Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand

Address of Corresponding Author

Horm Res 2005;64 (Suppl. 3):66-72 (DOI: 10.1159/000089320)

Key Words

Growth hormone
Brain
Development
Growth hormone receptor

Abstract

Growth hormone (GH) is integrally involved in the development of the central nervous system (CNS), as well as during its recovery from injury, two processes that share many similarities and may influence CNS functionality. This review discusses some of the most recent findings in the field and, in particular, the ontogeny, distribution, regulation and putative functions of GH and its receptor within the CNS, particularly during development. The relative roles of peripheral GH, acting in part through insulin-like growth factor-I, and of the autocrine/paracrine GH system within the brain are considered. The potential role of GH as a therapeutic agent to influence brain development and function is discussed.

Author Contacts

Dr. Arjan Scheepens
Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland
Private Bag 92019
Auckland (New Zealand)
Tel. +64 9 373 7599, ext. 86689, Fax +64 9 373 7497, E-Mail a.scheepens@auckland.ac.nz

Article Information

Published online: January 20, 2006
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 0, Number of References : 84

Medline Abstract (ID 16439847)

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