Imaging Acute Renal Failure with Polyamine Dendrimer-Based MRI Contrast Agents

Vol. 103, No. 2, 2006

Free Abstract Article (Fulltext) Article (PDF 543 KB)

Radiologic Imaging

Imaging Acute Renal Failure with Polyamine Dendrimer-Based MRI Contrast Agents
James W. Dear^a, Hisataka Kobayashi^b, Martin W. Brechbiel^c, Robert A. Star^a

^aRenal Diagnostics and Therapeutics Unit, NIDDK,
^bMolecular Imaging Program, Center for Cancer Research, NCI, and
^cRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Md., USA

Address of Corresponding Author

Nephron Clin Pract 2006;103:c45-c49 (DOI: 10.1159/000090608)

Key Words

MRI
Kidney
Imaging
Acute renal failure
Sepsis
Biomarker

Abstract

Acute renal failure (ARF) induced by sepsis has a high mortality but lacks effective treatments. To develop novel therapies we must diagnose renal injury early and accurately in septic patients and identify any additional insults such as nephrotoxic drugs and ischemia. In this short review we describe our experience using MRI with dendrimer-based contrast agents in mouse models of ARF. This technique can diagnose early renal injury before serum creatinine is elevated, distinguish different ARF etiologies, track drug therapy and predict outcome. As an ARF biomarker, MRI with dendrimer-based contrast is a promising technique deserving further development.

Author Contacts

Robert A. Star, MD
Renal Diagnostics and Therapeutics, NIDDK
10 Center Drive, Building 10, Room 3N108
Bethesda, MD 20892-1268 (USA)
Tel. +1 301 402 6749, Fax +1 301 402 0014, E-Mail starr@niddk.nih.gov

Article Information

Published online: March 10, 2006
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 0, Number of References : 23

Medline Abstract (ID 16543755)

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