Original Paper

Surgery for Hepatocellular Carcinoma Arising in Hereditary Hemochromatosis
Georgios C. Sotiropoulos^a, Ernesto P. Molmenti^a, Hauke Lang^a, Susanne Beckebaum^a, Gernot M. Kaiser^a, Eirini I. Brokalaki^a, Andrea Frilling^a, Massimo Malagó^a, Markus Neuhäuser^b, Christoph E. Broelsch<sup>a

a</sup>Department of General, Visceral and Transplantation Surgery, and
^bInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany

Address of Corresponding Author

Eur Surg Res 2006;38:371-376 (DOI: 10.1159/000094532)

  Key Words

• Hepatocellular carcinoma
• Hemochromatosis
• Resectability
• Liver resection
• Liver transplantation
• Transarterial chemoembolization

  Abstract

Background: Hepatocellular carcinoma (HCC) is a well-known complication of hereditary hemochromatosis. The benefit of surgical therapy in this clinical entity is not well documented. The purpose of this study was to evaluate the outcome of such patients both in our own experience as well as in the published literature. Methods: 320 patients with a diagnosis of HCC were evaluated at our institution to undergo either surgical resection (n = 262) or liver transplantation (n = 58) during the 4- year period from January 2001 to December 2004. We identified 5 patients with HCC arising in the setting of hemochromatosis. A literature search was performed to estimate resectability rates as well as outcomes after liver transplantation for HCC arising in hemochromatosis. Results: HCC was multifocal in 4 instances and solitary in 1 case. The liver was cirrhotic in all but 1 case. Three patients underwent an exploratory laparotomy, 1 an exploratory laparoscopy, and 1 underwent transplantation. HCC was unresectable in all cases. The patient with a solitary tumor and cirrhosis underwent 5 sessions of transarterial chemoembolization and is alive 37 months after surgical exploration. The 3 patients with multifocal tumors who underwent exploratory laparotomies died within 6 months after the intervention. The fifth patient who underwent a deceased donor split liver transplantation for multifocal tumor is alive without recurrence 3 years after transplantation. These results are similar to those in the literature that concur with the low resectability rate and the favorable outcome after liver transplantation. Conclusion: Resectability rates of HCCs arising in hemochromatosis are extremely low, given that tumors are usually multifocal and the livers cirrhotic in the majority of the instances. Early detection of hemochromatosis as well as intensive tumor screening of cirrhotic patients with hemochromatosis could possibly optimize the role of surgery or accelerate the decision to proceed with liver transplantation.

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Dr. Georgios C. Sotiropoulos, MD
Department of General, Visceral and Transplantation Surgery
University Hospital Essen, Hufelandstrasse 55, DE-45122 Essen (Germany)
Tel. +49 201 723 1102, Fax +49 201 723 1113
E-Mail georgios.sotiropoulos@uni-essen.de

  Article Information

Received: January 25, 2006
Accepted after revision: May 31, 2006
Published online: July 11, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 5, Number of References : 27