Original Paper

No Observable Relationship between the ACE Gene Insertion/Deletion Polymorphism and Psychometric IQ and Psychomotor Ability in Chinese Children
Jianjun Gao^{a, b, c}, Xiaocai Gao^d, Wei Qin^a, Fangli Dang^e, Fuchang Zhang^d, Xueqing Qian^a, Xiaoyang Zeng^e, Qinghe Xing^a, Zijian Zheng^d, Jun Li^a, Tingwei Guo^a, Hongfen Chang^{b, c}, Guoyin Feng^f, Lin He<sup>b, g

a</sup>Bio-X Center, Shanghai Jiao Tong University,
^bChangning Greenland Hospital,
^cInstitute for Neuropsychiatric Science and Metabonomics, Shanghai Jiao Tong University, Shanghai,
^dInstitute of Population and Health, Northwest University, Xi'an,
^eShanghai University of Finance and Economics,
^fShanghai Mental Health Center, and
^gInstitute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Address of Corresponding Author

Neuropsychobiology 2006;53:196-202 (DOI: 10.1159/000094728)

  Key Words

• Angiotensin I-converting enzyme gene
• Intelligence
• Cognition
• Psychomotor ability

  Abstract

The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Lin He
Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences
294 Taiyuan Road
Shanghai 200031 (China)
Tel./Fax +86 21 6282 2491, E-Mail helin@bio-x.cn

  Article Information

The first three authors contributed equally to this work.

Received: September 13, 2005
Accepted after revision: May 14, 2006
Published online: July 26, 2006
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 42