Original Paper

Quantitative Analysis of Chondroitin Sulfate in Tear Fluids following Laser in situ Keratomileusis
Masaya Nishio, Kiyomi Arai

Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan

Address of Corresponding Author

Ophthalmic Res 2006;38:274-279 (DOI: 10.1159/000095770)

  Key Words

• Chondroitin sulfate
• Laser in situ keratomileusis
• Tear fluid
• Wound healing
• Human

  Abstract

Purpose: To report chondroitin sulfate (CS) concentrations in tear fluid following laser in situ keratomileusis (LASIK). Methods: Fourteen eyes that underwent LASIK were enrolled. We measured the CS isomers chondroitin 4 sulfate and chondroitin 6 sulfate using an enzyme-linked immunosorbent assay preoperatively and postoperatively on days 1 and 4, week 1, and 1 and 3 months. Results: The chondroitin 4 sulfate concentration remained unchanged from preoperative values. The chondroitin 6 sulfate concentration increased temporarily 1 day postoperatively and gradually decreased thereafter. Conclusions: CS in tear fluids participates in wound healing after LASIK. Clarifying its role in tear fluids will contribute to improved LASIK outcomes.

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Masaya Nishio, MD
Department of Ophthalmology
Dokkyo Medical University Koshigaya Hospital
Koshigaya, Saitama 343-8555 (Japan)
Tel. +81 48 965 1111, Fax +81 48 965 1127, E-Mail m-nishio@dokkyomed.ac.jp

  Article Information

Received: October 1, 2005
Accepted after revision: April 8, 2006
Published online: September 15, 2006
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 25