Behavioural Measures in Frontotemporal Lobar Dementia and Other Dementias: The Utility of the Frontal Behavioural Inventory and the Neuropsychiatric Inventory in a National Cohort Study

Vol. 23, No. 6, 2007

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Original Research Article

Behavioural Measures in Frontotemporal Lobar Dementia and Other Dementias: The Utility of the Frontal Behavioural Inventory and the Neuropsychiatric Inventory in a National Cohort Study
M. Blair^a, A. Kertesz^a, N. Davis-Faroque^a, G.-Y.R. Hsiung^b, S.E. Black^c, R.W. Bouchard^d, S. Gauthier^e, D.A. Guzman^f, D.B. Hogan^g, K. Rockwood^h, H. Feldman^b

^aDepartment of Cognitive Neurology and Alzheimer's Research Centre, St. Joseph's Health Care, University of Western Ontario, London,
^bDepartment of Medicine (Neurology), University of British Columbia, Vancouver,
^cDepartment of Medicine (Neurology), University of Toronto, Toronto,
^dDepartment of Medicine (Neurology), Laval University, Québec,
^eMcGill Center for Studies in Aging, McGill University, Montreal,
^fDepartment of Medicine (Neurology), University of Ottawa, Ottawa,
^gDepartment of Medicine (Geriatric Medicine), University of Calgary, Calgary, and
^hDepartment of Medicine (Geriatric Medicine, Neurology), Dalhousie University, Halifax, Canada

Address of Corresponding Author

Dement Geriatr Cogn Disord 2007;23:406-415 (DOI: 10.1159/000101908)

Key Words

Frontotemporal lobar dementia
Frontotemporal dementia
Pick's disease
Pick complex
Alzheimer's disease
Alzheimer's type dementia
Frontal behavioural inventory
Neuropsychiatric inventory
Canadian Collaborative Cohort of Related Dementias

Abstract

Background: Distinguishing between patients with frontotemporal lobar dementia (FTLD) and other dementing illnesses remains a difficult task for many clinicians. In this study, we aimed to provide further evidence for the construct validity of the frontal behavioural inventory (FBI) and assess its utility in differentiating FTLD patients from other groups using data from the Canadian Collaborative Cohort of Related Dementias (ACCORD) study. Method: Baseline scores on the FBI and neuropsychiatric inventory (NPI) were compared among several clinical groups (n = 177). Results: The FBI discriminated a higher percentage of FTLD patients (>75% correct classification) from Alzheimer's disease and other groups compared to the NPI (54.2%). Conclusion: This study provides good evidence for convergent validity between the FBI and NPI (r = 0.72), indicating that both measures capture similar psychopathology in this nationwide cohort.

Author Contacts

Mervin Blair
Department of Cognitive Neurology, St Joseph's Health Care
London, Ont. N6A 4V2 (Canada)
Tel. +1 519 646 6000, ext. 64852, Fax +1 519 646 6226
E-Mail Mervin.Blair@sjhc.london.on.ca

Article Information

Accepted: May 21, 2006
Published online: April 20, 2007
Number of Print Pages : 10
Number of Figures : 3, Number of Tables : 3, Number of References : 47

Medline Abstract (ID 17446701)

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