Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer’s Disease and Mild Cognitive Impairment

Vol. 23, No. 6, 2007

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Original Research Article

Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer's Disease and Mild Cognitive Impairment
Aleksandra Maruszak^a, Krzysztof Safranow^b, Magdalena Gacia^a, Tomasz Gabryelewicz^a, Agnieszka S lstrok owik^c, Maria Styczy nacute ska^a, Beata Pep lstrok o nacute ska^a, Maciej P. Golan^a, Cezary Zdot ekanowski^a, Maria Barcikowska^a

^aDepartment of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw,
^bDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, and
^cDepartment of Neurology, Jagiellonian University, Cracow, Poland

Address of Corresponding Author

Dement Geriatr Cogn Disord 2007;23:432-438 (DOI: 10.1159/000101990)

Key Words

Alzheimer's disease
Mild cognitive impairment
Sigma receptor type 1 gene

Abstract

The sigma-1 receptor (SIGMAR1) is a subtype of a nonopioid sigma receptor family and is implicated in numerous functions connected with Alzheimer's disease (AD). Two common genetic variants were identified in SIGMAR1: GC-241 -240TT and Q2P (A61C). It was suggested that the TT-C haplotype is a protective factor for AD. We decided to investigate a putative link between the variants of SIGMAR1 and AD in a group of Polish patients with late-onset AD, in patients with mild cognitive impairment, and in a control group. We observed no significant differences for the SIGMAR1 allele, genotype, haplotype, and diplotype distributions between the studied groups. Multivariate logistic regression analysis showed no interaction between the APOE4 and SIGMAR1 polymorphisms. Further studies using data from different populations are required to elucidate the effect of SIGMAR1 polymorphisms on AD.

Author Contacts

Aleksandra Maruszak
Department of Neurodegenerative Disorders, Medical Research Centre
Polish Academy of Sciences, ul. Pawi nacute skiego 5
PL-02-106 Warszawa (Poland)
Tel. +48 22 608 64 85, Fax +48 22 668 55 32, E-Mail ola.maruszak@cmdik.pan.pl

Article Information

Accepted: March 6, 2007
Published online: April 23, 2007
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 5, Number of References : 28

Medline Abstract (ID 17457031)

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