Original Paper

Nonsteroidal Anti-Inflammatory Drugs and the Risk of Parkinson Disease
Marjolijn Bornebroek^{a, c}, Lonneke M.L. de Lau^{a, b}, Mendel D.M. Haag^a, Peter J. Koudstaal^b, Albert Hofman^a, Bruno H.C. Stricker^{a, d}, Monique M.B. Breteler^a

Departments of
^aEpidemiology and Biostatistics and
^bNeurology, Erasmus Medical Center, Rotterdam,
^cDepartment of Neurology, Leiden University Medical Center, Leiden, and
^dInspectorate for Health Care, The Hague, The Netherlands

Address of Corresponding Author

Neuroepidemiology 2007;28:193-196 (DOI: 10.1159/000108110)

  Key Words

• Nonsteroidal anti-inflammatory drugs
• Parkinson disease, inflammation
• Cohort study

  Abstract

Background: Several lines of evidence suggest a role of inflammatory processes in Parkinson disease, although it is still unclear whether inflammation is a cause or rather a consequence of neurodegeneration. Methods: In a prospective population-based cohort study among 6,512 participants aged 55 years, with repeated in-person examination, we evaluated the association between cumulative use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of Parkinson disease. Complete information on filled prescriptions was available from automated pharmacy records. Data were analyzed by means of Cox proportional hazards regression analysis, adjusted for age, sex, smoking habits and coffee consumption. Results: After an average 9.4 years of follow-up, 88 new cases of Parkinson disease were detected. No association was found between use of NSAIDs and the risk of Parkinson disease (adjusted hazard ratio for any NSAID use, 1.50; 95% confidence interval, 0.95-2.37). Conclusion: Our findings do not support the hypothesis that NSAIDs might decrease the risk of Parkinson disease.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

M.M.B. Breteler, MD, PhD
Department of Epidemiology and Biostatistics, Erasmus Medical Center
PO Box 1738
NL-3000 DR Rotterdam (The Netherlands)
Tel. +31 10 408 7930, Fax +31 10 408 9382, E-Mail m.breteler@erasmusmc.nl

  Article Information

Published online: September 11, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 13